“It is thought that many of the adverse effects of COVID-19 vaccine are triggered by the systemic inflammatory response.4 In addition, we know that the systemic inflammatory response causes modifications in brain physiology and has been related to the sepsis-associated delirium.5

This patient had several predisposing factors for delirium such as age, polypharmacy and sensitive impairment, and we consider that this vaccine-induced immune reaction was enough to disrupt his frail homeostasis.”-

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Zavala-Jonguitud, LF, Pérez-García, CC. Delirium triggered by COVID-19 vaccine in an elderly patient. Geriatr. Gerontol. Int. 2021; 21: 540. https://doi.org/10.1111/ggi.14163