Got Inflammation? Discover Urolithin A

We will discuss the amazing molecule Urolithin A. This molecule triggers autophagy to reduce inflammation, triggers mitophagy to heal mitochondrial disease, and triggers lysophagy to improve cell's recycling activities. The result is better neuronal protection, better muscle strength and efficiency, and reduced inflammation. In cancer cells this molecule triggers apoptosis leading to reduced cancer cell viability or death.

References:

Targeting aging with urolithin A in humans: A systematic review - ScienceDirect

https://www.sciencedirect.com/science...

mTOR and autophagy: A dynamic relationship governed by nutrients and energy - ScienceDirect

https://www.sciencedirect.com/science...

Discovery of the molecular mechanisms responsible for deficient autophagy and the protective effect of urolithin A in age-related macular degeneration | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas

https://www.cib.csic.es/news/research...

Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration | Molecular Neurodegeneration | Full Text

https://molecularneurodegeneration.bi...

Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration via the AMPK signaling pathway - ScienceDirect

https://www.sciencedirect.com/science...

An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages - ScienceDirect

https://www.sciencedirect.com/science...

Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway - ScienceDirect

https://www.sciencedirect.com/science...

Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects - PMC

https://pmc.ncbi.nlm.nih.gov/articles....

Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells - PMC

https://pmc.ncbi.nlm.nih.gov/articles...

Frontiers | Urolithin A targets the AKT/WNK1 axis to induce autophagy and exert anti-tumor effects in cholangiocarcinoma

https://www.frontiersin.org/journals/...

Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway - Zhang - 2023 - Drug Development Research - Wiley Online Library

https://analyticalsciencejournals.onl...

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults - PubMed

https://pubmed.ncbi.nlm.nih.gov/35584...

Urolithin A‐activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo - PMC

https://pmc.ncbi.nlm.nih.gov/articles...

Urolithin A alleviates neuropathic pain and activates mitophagy - PMC

https://pmc.ncbi.nlm.nih.gov/articles...

Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions - Hou - 2024 - Alzheimer's & Dementia - Wiley Online Library

https://alz-journals.onlinelibrary.wi...

Urolithin-A-Cognitive-Vitality-For-Researchers.pdf

https://www.alzdiscovery.org/uploads/...

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice | Journal of Neuroinflammation | Full Text

https://jneuroinflammation.biomedcent...

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