Spikeopathies – How Spike Protein Causes Clotting

Spike Protein and Platelet Activation: Mechanisms, Microclots, and Therapeutic Insights

In this lecture, Dr. Mobeen Syed explores how the SARS-CoV-2 spike protein can trigger platelet activation and clot formation through multiple pathways—including ACE2 downregulation, integrin binding, complement activation, and direct platelet signaling.

Topics Covered:

How spike protein affects ACE2 and promotes Ang II / AT1R overactivation

The role of integrin αvβ3 binding and MAPK signaling in platelet activation

Complement system activation (C3a, C5a, MAC) and its link to thrombosis

Key markers of platelet activation: aggregation, PAC-1 binding, P-selectin expression, granule release, and clot retraction

Established and emerging therapies: ARBs, antiplatelets (aspirin, clopidogrel), anticoagulants, complement inhibitors, and natural fibrinolytics (nattokinase, lumbrokinase)

Link to the Study

This talk is designed for clinicians, medical students, and researchers seeking to understand the immunological patterns seen in PCVS and Long COVID-like presentations.

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.